간만에 5 FU에 대하여 review를 해본다.
레지던트셤본다고 꺼내본뒤 어언 6개월만에 찾아보니 다음과 같다.
찾는김에 Xeroda같은 약도 참 오랜만에 들어본다 . 학생실습때 퀴즈형식으로 Hand fo
5-Fluorouracil (Adrucil, Efudex)—5-FU
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Drug Class: Pyrimidine antimetabolite; inhibitor of thymidylate synthase. Partially cell cycle dependent. |
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Dosage Form: Available in solution in 0.5- to 5-γ ampules or vials at a concentration of 50 mg/mL. |
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Drug Interactions: None noted. |
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Pharmacokinetics/Metabolism: Parental bioavailability only. After an intravenous dose, 80% of the drug is metabolized to the inactive dihydro-5-FU by dihydropyrimidine dehydrogenase in the liver. The rest of the drug is activated to fluorodeoxyuridine monophosphate in the target cells. The elimination half-life is about 20 minutes. Excretion is via the kidneys.
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Toxicity: GI toxicities, primarily mucositis for bolus injections and diarrhea for prolonged infusions, are dose limiting. Rare patients with dihydropyrimidine dehydrogenase deficiency have excessive GI toxicity. Myelosuppression is generally less with continuous infusion schedules. Nausea and vomiting are uncommon and mild. Dermatitis and other cutaneous toxicities, including hand-foot syndrome, are common. Cerebellar ataxia and myocardial ischemia are rare.
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Indications: FDA approved for colon, rectum, gastric, pancreas, and breast carcinomas and used for a wide range of other neoplasms in combination regimens. Used for intrahepatic arterial infusion for liver metastases from GI tumors; also used topically for various cutaneous neoplasms and disorders. |
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Dosing: IV dosing schemes include weekly bolus, 5 days of bolus every 28 days, 4 to 5 day continuous infusions. Doses range from 300 to 3000 mg/m2/day depending on the dosing scheme and schedule. |
출처는 Abeloff: Abeloff's Clinical Oncology,
4th ed. ㅎㅎ
